Most of the main, dependable hotel accommodations are located on the western side of the Ozama River, along the Malecon and in the Zona Colonial. Those along the Malecon are mostly large-scale international chain hotels with casinos, and they're generally noisy at night and on weekends. The Zona Colonial boasts more intimate hotels, many of them that make the most of their colonial ambience.
For longer stays, try the serviced apartments in the Naco neighborhood, which also has mid-priced international chain hotels. However, there is no advantage to being this far west unless you are in town on business or for a long stay.
Be aware that "motels" are usually rented by the hour by amorous couples and not actually geared to tourists, despite the name.
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