The winter storm continued to target the Great Lakes and Central Plains regions Wednesday before beginning its move toward the Northeast later in the week.
More than 300 flights were canceled out of Chicago Wednesday morning, with major airports along the East Coast seeing significant delays and backups, according to FlightStats.
More cancellations were expected as the day wore on.
Carriers canceled 1,574 flights nationwide on Tuesday, bringing the total number of cancellations since Sunday to 3,241.
Most airlines have issued flexible rebooking policies for passengers with flights to, from or through the airports in the storm's path. Follow Gay Nagle Myers on Twitter @gnmtravelweekly.