American Cruise Lines offers 51-day itinerary in 2025

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The American Serenade will sail the Mississippi from New Orleans to Minnesota during the Great United States itinerary.
The American Serenade will sail the Mississippi from New Orleans to Minnesota during the Great United States itinerary. Photo Credit: American Cruise Lines

American Cruise Lines said it will offer one of the longest river cruise packages ever sold in the U.S., spanning 51 days on three rivers on three ships.

The Great United States itinerary starts in Portland, Ore. On May 30, the American Jazz departs Portland, spending the first eight days on the Columbia and Snake rivers.

Days 9 to 15 are a coach exploration of Yellowstone, Grand Teton and Glacier national parks, finishing in Jackson Hole, Wyo., where guests will board a plane to New Orleans.

Days 16 to 36 will be spent on the Mississippi River on the American Serenade, headed northward toward Redwing, Minn. Guests then fly from Minneapolis/St. Paul to Boston. There, they board the American Patriot coastal ship for a 15-day cruise along the New England coast before returning to Boston on Day 51.

American Cruise Lines does not list pricing for the cruise on its website, but directs prospects to a phone number to request a quote.

The company is also offering a 36-day Civil War Battlefield itinerary in 2025 that explores 12 states and 20 Civil War Battlefields on three ships sailing from May 6 to June 10.

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